Publications


2016

Neural Pain Circuits: recent advances and current views. 
Peirs C, Seal RP.
Science (2016) 354(6312):578-584. Review.
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Illuminating the Gap: Neuronal Cross-Talk within Sensory Ganglia and Persistent Pain. 
Seal RP.
Neuron (2016) 91: 950-951
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Do the Distinct Synaptic Properties of VGLUTs Shape Pain? 
Seal RP.
Neurochem Int. (2016) 98:82-88. Review
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Ensuring Transparency and Minimization of Methodologic Bias in Preclinical Pain Research: PPRECISE Considerations.  Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice AS, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I, McDermott MP, McMahon SB, Price TJ, Ross SE, Scherrer G, Seal RP, Sena ES, Silva E, Stone L, Svensson CI, Turk DC, Whiteside G.
Pain 157(4):901-9.
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Affective Touch and the Neurophysiology of CT Afferents.
Seal RP and Lumpkin EA. (2016) Cell Biology of Tactile Afferents. (Springer) Book Chapter In press

2015

Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson’s Disease. 
Divito CB, Steece-Collier K, Case DT, Williams SP, Stancati JA, Zhi L, Rubio ME, Sortwell CE, Collier TJ, Sulzer D, Edwards RH, Zhang H, Seal RP.
J Neurosci. (2015) 35(45):14983-99.
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Targeting Toll-like receptors to treat chronic pain. 
Peirs C, Seal RP.
Nat Med. (2015) 21(11):1251-2.
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Dorsal Horn Circuits for Persistent Mechanical Pain
Peirs C, Williams SPG, Zhao X, Walsh CE, Gedeon JY, Cagle NE, Goldring AC, Hioki H, Liu Z, Marell PS, Seal RP.
Neuron. 87(4):797-812.
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VGLUT3-independent Communication from Cochlea to Brain Detects Tissue-damaging Noise.  
Flores EN, Madathany T, Hogan AK, Kumar G, Seal RP, Edwards RH, Liberman MC, and Garcia-Anoveros J.
Curr. Biol. 25(5): 606-612.

Presynaptic Inhibition of Optogenetically Identified VGluT3+ Sensory Fibres by Opioids and Baclofen.
Honsek S, Seal RP, and Sandkühler J.
Pain 156(2): 243-251.

2014


A Glutamatergic Reward Input from the Dorsal Raphe to Ventral Tegmental Area Dopamine Neurons.
Qi J, Zhang S, Wang HL, Wang H, Aceves Buendia J, Hoffman A, Lupica C, Seal RP, and Morales M.
Nat. Comm. 5 (5390).

An Unconventional Glutamatergic Circuit in the Retina Formed by vGluT3 Amacrine Cells.
Lee S*, Chen L*, Chen M*, Ye M, Seal RP, and Zhou ZJ.
Neuron 84(4): 1-8.

 A Novel Population of Glomerular Neurons Controls Sensory Information Transfer in the Mouse Olfactory Bulb.
Tatti R*, Bhaukaurally K*, Gschwend O*, Seal RP, Edwards RH, Rodriguez I, and Carleton A.   
Nat. Comm. 5: 3791.

Striatal Cholinergic Neurotransmission Requires VGLUT3.
Nelson AB, Bussert TG, Kreitzer AC, Seal RP.
J Neurosci. 34(26):8772-7.
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Striatal cholinergic interneurons drive GABA release from dopamine terminals. 
Nelson AB, Hammack N, Yang CF, Shah NM, Seal RP, Kreitzer AC.
Neuron.82(1):63-70.
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2013


TAFA4, a Chemokine-Like Protein, Modulates Injury-Induced Mechanical and Chemical Pain Hypersensitivity in Mice.  
Delfini MC, Mantilleri A, Gaillard S, Hao J, Reynders A, Malapert P, Alonso S, Francois A, Barrere C, Seal R, Landry M, Eschallier A, Alloui A, Bourinet E, Delmas P, Le Feuvre Y, Moqrich A.
Cell Rep. 5(2): 378-388.

Transcript Expression of Vesicular Glutamate Transporters in Lumbar Dorsal Root Ganglia and the Spinal Cord of Mice-Effects of Peripheral Axotomy or Hindpaw Inflamation.  
Malet M, Vieytes CA, Lundgren KH, Seal RP, Tomasella E, Seroogy KB, Hökfelt T, Gebhart GF, Brumovsky PR.
Neuroscience. 248C: 95-111.

Expression of Vesicular Glutamate Transporters in Sensory and Autonomic Neurons Innervating the Mouse Bladder.  
Brumovsky PR, Seal RP, Lundgren KH, Seroogy KB, Watanabe M, Gebhart GF.
J Urol. 89(6): 2342-2349.

2012


Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy.
Akil O, Seal RP, Burke K, Wang C, Alem A, During MJ, Edwards RH, Lustig LR.
Neuron. 75(2):283-93.
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NA(v)1.8 expression is not restricted to noiceptors in mouse peripheral nervous system.
Shields SD, Ahn HS, Yang Y, Han C, Seal RP, Wood JN, Waxman SG and Dib-Hajj SD.
Pain 153 (10): 2017-2030.

2011


Genetic Targeting and Physiological Features of VGLUT3+ Amacrine Cells.
Grimes, WN*, Seal, RP*, Oesch, NW*, Edwards, RH and Diamond, JS.
Vis. Neurosci. 5:381-392.

Expression of vesicular glutamate transporters type 1 and 2 in sensory and autonomic neurons innervating the mouse colorectum.
Brumovsky PR, Robinson DR, La JH, Lundgren KH, Albers KM, Kiyatkin ME, Seal RP, Edwards RH, Watanabe M, Hökfelt T, Gebhart GF.
J Comp Neurol.  Epub DOI: 10.1002/cne.22730
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Cholinergic Interneurons Mediate Fast VGluT3-dependent Glutamatergic Transmission in the Striatum.
Higley MJ*, Gittis A*, Oldenberg, IA*, Balthasar N, Seal RP, Edwards RH, Lowell BB, Kreitzer AC, and Sabatini BL.
 PLoS One 6(4): e19155.

2010


Glutamate release at GABA/glycinergic Synapses is Critical for the Refinement of an Inhibitory Map.
Noh J, Seal RP, Garver, JA, Edwards RH, and Kandler K.
Nature Neurosci. 13(2): 232-238.  PMCID: PMC2832847.

2009 

Injury–Induced Mechanical Hypersensitivity requires C-Low Threshold Mechanoreceptors.
Seal RP*, Wang X*, Guan Y, Raja SN, Woodbury CJ, Basbaum AI, and Edwards, RH.
Nature 462: 651-655. PMCID: PMC2810205.  *See News and Views by Drew and MacDermott. Nature 462: 580-581.

Synaptic and Extrasynaptic Factors Governing Glutamatergic Retinal Waves.
Blankenship AG, Ford KJ, Johnson, J, Seal RP, Edwards RH, Copenhagen DR, and Feller MB.
Neuron  62 (2): 230-241.  PMCID: PMC2807181.

2008


Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3.
Seal RP, Akil O, Yi E, Weber CM, Grant L, Yoo J, Clause A, Kandler K, Noebels JL, Glowatzki E, Lustig LR, Edwards RH.
Neuron. 2008 Jan 24;57(2):263-75.
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Can One Neuron Release More than One Neurotransmitter?  Ask the Brains.
Seal RP.
Scientific American Mind  August Issue

2006


The Diverse Roles of Vesicular Glutamate Transporter 3.
Seal RP and Edwards RH.
Handb. Exp. Pharmacol.175: 137-150. Review

Functional Implications of Neurotransmitter Co-release: Glutamate and GABA Share the Load.
Seal RP
and Edwards RH.
Curr. Opin. Pharmacol.  6 (1): 114-119. Review